3-Methyladipic acid( —— )

Catalog No. M19985 CAS No. 3058-01-3

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Product Name

3-Methyladipic acid
Note

Research use only, not for human use.
Brief Description

3-Methyladipic acid is a metabolite of the catabolism of phytanic acid. Patients with adult Refsums disease (ARD) are unable to detoxify phytanic acid by alpha-oxidation and so the w-oxidation pathway is the only metabolic pathway available for phytanic acid degradation.
Description

3-Methyladipic acid is a metabolite of the catabolism of phytanic acid. Patients with adult Refsums disease (ARD) are unable to detoxify phytanic acid by alpha-oxidation and so the w-oxidation pathway is the only metabolic pathway available for phytanic acid degradation. This pathway produces 3-methyladipic acid as the final metabolite which is excreted in the urine.
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1.Wierzbicki AS et al. Refsum's disease: a peroxisomal disorder affecting phytanic acid alpha-oxidation. J Neurochem. 2002 Mar;80(5):727-35.

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